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Title: Lack of association between human immunodeficiency virus type 1 antibody in cervicovaginal lavage fluid and plasma and perinatal transmission, in Thailand
Authors: Rutt Chuachoowong
Nathan Shaffer
Thomas C. VanCott
Pongsakdi Chaisilwattana
Wimol Siriwasin
Naris Waranawat
Nirun Vanprapar
Nancy L. Young
Timothy D. Mastro
John S. Lambert
Merlin L. Robb
Mahidol University
Rajavithi Hospital
Queen Sirikit National Institute of Child Health
HIV/AIDS Collaboration
Centers for Disease Control and Prevention
Walter Reed Army Institute of Research
University of Maryland, Baltimore
Thailand Ministry of Public Health
Keywords: Immunology and Microbiology;Medicine
Issue Date: 10-Jul-2000
Citation: Journal of Infectious Diseases. Vol.181, No.6 (2000), 1957-1963
Abstract: To determine the association between human immunodeficiency virus type 1 (HIV) - specific antibody and RNA levels in cervicovaginal lavage (CVL) samples and plasma, zidovudine treatment, and perinatal transmission, HIV subtype E gp 160-specific IgG and IgA were serially measured in a subset of 74 HIV-infected women in a placebo-controlled trial of zidovudine, beginning at 36 weeks of gestation. HIV IgG was detected in 100% of plasma and 97% of CVL samples; HIV IgA was consistently detected in 62% of plasma and 31% of CVL samples. Antibody titers in CVL samples correlated better with the RNA level in CVL samples than with plasma antibody titers. Zidovudine did not affect antibody titers. Perinatal HIV transmission was not associated with antibody in CVL samples or plasma. HIV-specific antibody is present in the cervicovaginal canal of HIV-infected pregnant women; its correlation with the RNA level in CVL fluid suggests local antibody production. However, there was no evidence that these antibodies protected against perinatal HIV transmission.
ISSN: 00221899
Appears in Collections:Scopus 1991-2000

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