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Title: Resetting of Plasmodium falciparum required multiple components of the uninfected erythrocytes
Authors: Busaba Pipitaporn
Tada Sueblinvong
Ayut Dharmkrong-at
Rachanee Udomsangpetch
Rangsit University
Chulalongkorn University
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2000
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.18, No.1 (2000), 29-35
Abstract: The mechanism of rosette formation of uninfected erythrocytes with Plasmodium falciparum-infected erythrocytes is rarely described. In this study, resetting of uninfected normal erythrocytes with infected erythrocytes significantly reduced after treatment of the uninfected erythrocytes with neuraminidase. In contrast, the resetting property of the infected erythrocytes was abolished by trypsinization but not by neuraminidase. The in vitro resetting model showed that uninfected thalassemic erythrocytes poorly formed rosettes with infected normal erythrocytes when compared with normal erythrocytes of the same blood group. A resetting parasite clone showed significant reduction in resetting with thalassemic erythrocytes of all blood groups, however, this reduction was not obvious when the wild P. falciparum isolates were studied. These results suggest that while parasites from a single clone can rosette with uninfected erythrocytes via carbohydrate component, there is more than one type of receptor on uninfected erythrocytes involved in rosette formation with the heterogeneous populations of the wild P. falciparum isolates.
ISSN: 0125877X
Appears in Collections:Scopus 1991-2000

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