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dc.contributor.authorA. Brockmanen_US
dc.contributor.authorR. N. Priceen_US
dc.contributor.authorM. Van Vugten_US
dc.contributor.authorD. G. Heppneren_US
dc.contributor.authorD. Walshen_US
dc.contributor.authorP. Sooktoen_US
dc.contributor.authorT. Wimonwattrawateeen_US
dc.contributor.authorS. Looareesuwanen_US
dc.contributor.authorN. J. Whiteen_US
dc.contributor.authorF. Nostenen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherJohn Radcliffe Hospitalen_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciences, Thailanden_US
dc.contributor.otherAcademic Medical Centre, University of Amsterdamen_US
dc.date.accessioned2018-09-07T09:12:51Z-
dc.date.available2018-09-07T09:12:51Z-
dc.date.issued2000-01-01en_US
dc.identifier.citationTransactions of the Royal Society of Tropical Medicine and Hygiene. Vol.94, No.5 (2000), 537-544en_US
dc.identifier.issn00359203en_US
dc.identifier.other2-s2.0-0033793944en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033793944&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/26011-
dc.description.abstractFollowing a marked decline in the efficacy in vivo of mefloquine between 1990 and 1994, a combination of artesunate (4 mg/kg/d for 3 d) and mefloquine (25 mg/kg) has been used as first line treatment of uncomplicated falciparum malaria in camps for displaced persons located along the north-western border of Thailand. Antimalarial drug susceptibility of fresh isolates of Plasmodium falciparum from this population was evaluated using a radioisotope microdilution assay between 1995 and 1999. In total, 268 isolates were collected, of which 189 were from primary infections and 79 from recrudescent infections. The geometric mean 50% inhibitory concentration (IC50) values from primary infections were: dihydroartemisinin 1.2 ng/mL, artesunate 1.6 ng/mL, artemether 4.8 ng/mL, atovaquone 0.4 ng/mL, lumefantrine 32 ng/mL, chloroquine 149 ng/mL, quinine 354 ng/mL, mefloquine 27 ng/mL and halofantrine 4.1 ng/mL. A significant positive correlation was found between the susceptibility in vitro to artesunate and quinine (r = 0·43, P < 0·001), mefloquine (r = 0·46, P < 0·001), and halofantrine (r = 0·51, P < 0.001). These levels of resistance in vitro are among the highest reported and confirm continuing high level multidrug resistance in this area. Despite intensive use of the combination between 1995 and 1999 there has been a significant improvement in mefloquine sensitivity (P < 0.001) and artesunate sensitivity (P < 0·001). This supports observations in vivo that the combination of artesunate and mefloquine has reversed the previous decline in mefloquine sensitivity.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033793944&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titlePlasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquineen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1016/S0035-9203(00)90080-4en_US
Appears in Collections:Scopus 1991-2000

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