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dc.contributor.authorM. Van Vugten_US
dc.contributor.authorS. Looareesuwanen_US
dc.contributor.authorP. Wilairatanaen_US
dc.contributor.authorR. McGreadyen_US
dc.contributor.authorL. Villegasen_US
dc.contributor.authorI. Gathmannen_US
dc.contributor.authorR. Mullen_US
dc.contributor.authorA. Brockmanen_US
dc.contributor.authorN. J. Whiteen_US
dc.contributor.authorF. Nostenen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherAcademic Medical Centre, University of Amsterdamen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherMinistry of Healthen_US
dc.contributor.otherNovartis International AGen_US
dc.contributor.otherJohn Radcliffe Hospitalen_US
dc.identifier.citationTransactions of the Royal Society of Tropical Medicine and Hygiene. Vol.94, No.5 (2000), 545-548en_US
dc.description.abstractThe efficacy and safety of the 6-dose regimen of artemether-lumefantrine were assessed in an open randomized trial in children and adults presenting with acute, uncomplicated Plasmodium falciparum malaria in Thailand between November 1997 and March 1998. 200 patients were enrolled in 2 centres: 150 received artemether-lumefantrine (i.e., a median total dose of 9.6 mg/kg [interquartile range 8.7-10.7] and 57.9 mg/kg of lumefantrine [52.4-64.0]) and 50 the standard combination of artesunate (12 mg/kg over 3 d) and mefloquine (25 mg/kg). All patients had rapid initial clinical and parasitological responses. The 28 d cure rates were high: 97.7% (95% confidence interval [95% CI] 93.5-99.5%) for artemether-lumefantrine and 100% (95% CI 92.5-100%) for artesunate-mefloquine. The 6-dose regimen of artemether-lumefantrine was better tolerated than, and as effective as, artesunate-mefloquine, the current standard treatment in this area of multidrug-resistant P. falciparum malaria.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleArtemether-lumefantrine for the treatment of multidrug-resistant falciparum malariaen_US
Appears in Collections:Scopus 1991-2000

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