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dc.contributor.authorYoshimasa Maenoen_US
dc.contributor.authorPeter Perlmannen_US
dc.contributor.authorHedvig Perlmannen_US
dc.contributor.authorYasuhiro Kusuharaen_US
dc.contributor.authorKoki Taniguchien_US
dc.contributor.authorToshio Nakabayashien_US
dc.contributor.authorKyaw Winen_US
dc.contributor.authorSornchai Looareesuwanen_US
dc.contributor.authorMasamichi Aikawaen_US
dc.contributor.otherTokai Universityen_US
dc.contributor.otherFujita Health University School of Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherDepartment of Molecular Biosciences, The Wenner-Gren Instituteen_US
dc.contributor.otherEmbassy of the Union of Myanmaren_US
dc.contributor.otherFujita Health Universityen_US
dc.identifier.citationAmerican Journal of Tropical Medicine and Hygiene. Vol.63, No.3-4 (2000), 128-132en_US
dc.description.abstractPostmortem brain tissues of 21 cerebral malaria cases were obtained in Myanmar and Vietnam. The tissues were examined Dy light microscopy and by an immunohistochemical method. Brain microvessels (capillaries and venules) were examined for the presence of immunoglobulins IgE and IgG, Plasmodium falciparum antigen, and parasitized erythrocytes (PRBC). Deposition of IgE, IgG, and P. falciparum antigen was observed in the microvessels from all specimens examined. Sequestered PRBC in the microvessels were positive for IgG in all 21 cases and for IgE in six cases. In the latter cases, the percentage of microvessels with sequestered PRBC was > 50%, with the frequency of IgE-positive cells ranging from 42% to 52%. In contrast, in five cases that were only weakly positive for IgE, the percentage of microvessels with sequestered PRBC was remarkably low (< 1%). These data indicate that the degree of deposition of IgE in microvessels and on PRBC from cerebral malaria patients correlated with that of PRBC sequestration. As IgE-containing immune complexes are known to induce local overproduction of tumor necrosis factor-alpha (TNF-α), a major pathogenic factor in cerebral malaria, IgE may contribute to the pathogenesis of this severe disease.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleIgE deposition in brain microvessels and on parasitized erythrocytes from cerebral malaria patientsen_US
Appears in Collections:Scopus 1991-2000

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