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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/26074
Title: Photodynamic therapy in management of head and neck cancers and precancerous lesions
Authors: Boonchu Kulapaditharom
Vipa Boonkitticharoen
Mahidol University
Keywords: Medicine
Issue Date: 1-Dec-2000
Citation: Journal of the Medical Association of Thailand. Vol.83, No.3 (2000), 249-258
Abstract: Photodynamic therapy (PDT) is a new form of cancer treatment with low morbidity. In this study, PDT was evaluated for its effectiveness in management of recurrent or widespread precancerous lesions, primary cancers in inoperable sites, recurrent or residual cancers which were refractory to radiotherapy and chemotherapy, and advanced tumors in the head and neck. Fifty-one patients were treated over a period of 5 years. A 91.67 per cent complete response rate was observed for T1tumors (primary and recurrence) with a recurrent rate of 27.27 per cent. Nasopharyngeal carcinoma was highly responsive to PDT since all T1and T2tumors responded completely. This was in contrast to cancers in the soft palate which failed in most cases possibly due to inadequate light dose distribution. PDT was remarkably effective in curing premalignant diseases (100% complete response rate). Postoperative PDT was equally effective in treating the microscopic residual malignancy. For advanced tumors, PDT in adjunct to conventional modalities could induce complete response in 5 out of the 10 patients and resolve symptoms in 4 cases. The mean follow-up time for this series was 28.3 months (range 3-66 months). In conclusion, PDT is a useful modality for the treatment of head and neck tumors and precancerous lesions presenting in forms or under conditions that posed considerable difficulties in management by conventional approaches.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034151820&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/26074
ISSN: 01252208
Appears in Collections:Scopus 1991-2000

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