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Title: Absence of knobs on parasitized red blood cells in a splenectomized patient in fatal falciparum malaria
Authors: Emsri Pongponratn
Parnpen Viriyavejakul
Polrat Wilairatana
David Ferguson
Urai Chaisri
Gareth Turner
Sornchai Looareesuwan
Mahidol University
University of Oxford
Keywords: Medicine
Issue Date: 1-Dec-2000
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.31, No.4 (2000), 829-835
Abstract: We present a case report of fatal falciparum malaria of a splenectomized adult Thai patient. The patient developed high peripheral parasitemia and showed signs of severe malaria with multiorgans involvement. Ultrastructure of Plasmodium falciparum -infected red blood cells in a fatal splenectomized patient and pathological features are reported for the first time with special emphasis on the role of the spleen as a modulating cytoadherence phenotype of parasitized red blood cells (PRBC). In this patient, adherence of the PRBC to the vascular endothelium of brain, kidney and lung including blood circulating cells, was noted, despite the absence of knob on the surface of the PRBC.
ISSN: 01251562
Appears in Collections:Scopus 1991-2000

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