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Title: | Analytical and clinical performance of two homogeneous assays for measuring of LDL-cholesterol |
Authors: | Wattana Leowattana Somjai Narkrung Sasikant Pokum Sudcharee Kiartivich Mahidol University |
Keywords: | Medicine |
Issue Date: | 1-Nov-2000 |
Citation: | Journal of the Medical Association of Thailand. Vol.83, No.SUPPL. 2 (2000) |
Abstract: | A clinical laboratory currently estimates LDL-Cholesterol (LDL-C) concentration using the Friedewald calculation, which requires fasting specimens and is subject to error with increasing triglycerides levels. We evaluated the analytical and clinical performance of the direct LDL-C assay from two companies, Roche Diagnostics (LDL-CRoche) and Wako Pure Chemical (LDL-CWako). Both methods meet current guidelines for precision with within-run coefficients of variation less than 3 per cent. The LDL-CRoche assay correlated well with the LDL-C from the Friedewald equation (LDL-CFried' r = 0.958, y = 0.85x + 17.08 mg/dL, n = 422). The LDL-CWako assay also correlated with the LDL-CFried (r = 0.946, y = 0.86x + 7.81 mg/dL, n = 422). In addition, at the medical decision cutoff points, LDL-CRoche assay and LDL-CWako showed positive predictive values of 87.44 per cent and 69.67 per cent respectively. We conclude that the LDL-CRoche assay meets the currently established analytical and clinical performance, but LDL-CWako assay meets only analytical performance. Clinical performance needs further evaluation. |
URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034330301&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/26126 |
ISSN: | 01252208 |
Appears in Collections: | Scopus 1991-2000 |
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