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Title: Serum cardiac troponin T in unstable angina pectoris patients
Authors: Wattana Leowattana
Nithi Mahanonda
Kiertijai Bhuripanyo
Sasikant Pokum
Sudcharee Kiartivich
Mahidol University
Keywords: Medicine
Issue Date: 1-Nov-2000
Citation: Journal of the Medical Association of Thailand. Vol.83, No.SUPPL. 2 (2000)
Abstract: Cardiac troponin T (cTnT) is a regulatory contractile protein not normally found in blood, Its detection in the circulation has been shown to be a sensitive and specific marker for myocardial cell damage. In this study, we used a second-generation enzyme immunoassay for cTnT to determine whether its presence in the serum of patients with unstable angina was a prognostic indicator. Thirty patients with unstable angina peetoris (UAP) and 30 patients with Q-wave acute myocardial infarction (AMI) were screened for serum CK-MB activity and cTnT at 6, 12, 24 and 48 hours after the onset of chest pain, All of the mean concentrations of CK-MB activity determined in UAP patients were less than the upper limit of normal (25 U/L). Meanwhile, the mean concentration of cTnT at 6, 12, 24 and 48 hours after onset of chest pain were higher than the cutoff values (0,1 μg/L), We found that one third of UAP patients had serum cTnT at the time of admission more than 0.1 μg/L and that these groups of patients were associated with a high risk for cardiac events. Our results suggested that patients with elevated serum cTnT could be considered as high-risk patients for developing myocardial infarction, Patients with normal cTnT levels and a low or intermediate clinical risk could be stabilized and further stratified noninvasively,.
ISSN: 01252208
Appears in Collections:Scopus 1991-2000

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