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dc.contributor.authorFanny N. Lauwen_US
dc.contributor.authorAndrew J.H. Simpsonen_US
dc.contributor.authorC. Erik Hacken_US
dc.contributor.authorJan M. Prinsen_US
dc.contributor.authorAngela M. Wolbinken_US
dc.contributor.authorSander J.H. Van Deventeren_US
dc.contributor.authorWipada Chaowagulen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorTom Van Der Pollen_US
dc.contributor.otherAcademic Medical Centre, University of Amsterdamen_US
dc.contributor.otherStichting Sanquin Bloedvoorzieningen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherSappasitthiprasong Hospitalen_US
dc.contributor.otherJohn Radcliffe Hospitalen_US
dc.identifier.citationJournal of Infectious Diseases. Vol.182, No.1 (2000), 206-213en_US
dc.description.abstractExtracellular release of granzymes is considered to reflect the involvement of cytotoxic T lymphocytes and NK cells in various disease states. To obtain insight into granzyme release during bacterial infection, granzyme levels were measured during experimental human endotoxemia and in patients with melioidosis, a severe infection due to gram-negative bacteria. Plasma concentrations of granzyme A (GrA) and GrB increased transiently after endotoxin administration, peaking after 2-6 h. In patients with bacteremic melioidosis, GrA and GrB levels were elevated on admission and remained high during the 72-h study period. In whole blood stimulated with heat-killed Burkholderia pseudomallei, neutralization of tumor necrosis factor, interleukin-12, or interleukin-18 inhibited granzyme secretion, which was independent of interferon-γ. Stimulation with endotoxin and other gram- negative and gram-positive bacteria also strongly induced the secretion of granzymes, suggesting that granzyme release is a general immune response during bacterial infection. The interaction between the cytokine network and granzymes may play an important immunoregulatory role during bacterial infections.en_US
dc.rightsMahidol Universityen_US
dc.titleSoluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteriaen_US
Appears in Collections:Scopus 1991-2000

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