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Title: Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria
Authors: Fanny N. Lauw
Andrew J.H. Simpson
C. Erik Hack
Jan M. Prins
Angela M. Wolbink
Sander J.H. Van Deventer
Wipada Chaowagul
Nicholas J. White
Tom Van Der Poll
Academic Medical Centre, University of Amsterdam
Stichting Sanquin Bloedvoorziening
Mahidol University
Sappasitthiprasong Hospital
John Radcliffe Hospital
Keywords: Medicine
Issue Date: 12-Aug-2000
Citation: Journal of Infectious Diseases. Vol.182, No.1 (2000), 206-213
Abstract: Extracellular release of granzymes is considered to reflect the involvement of cytotoxic T lymphocytes and NK cells in various disease states. To obtain insight into granzyme release during bacterial infection, granzyme levels were measured during experimental human endotoxemia and in patients with melioidosis, a severe infection due to gram-negative bacteria. Plasma concentrations of granzyme A (GrA) and GrB increased transiently after endotoxin administration, peaking after 2-6 h. In patients with bacteremic melioidosis, GrA and GrB levels were elevated on admission and remained high during the 72-h study period. In whole blood stimulated with heat-killed Burkholderia pseudomallei, neutralization of tumor necrosis factor, interleukin-12, or interleukin-18 inhibited granzyme secretion, which was independent of interferon-γ. Stimulation with endotoxin and other gram- negative and gram-positive bacteria also strongly induced the secretion of granzymes, suggesting that granzyme release is a general immune response during bacterial infection. The interaction between the cytokine network and granzymes may play an important immunoregulatory role during bacterial infections.
ISSN: 00221899
Appears in Collections:Scopus 1991-2000

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