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|Title:||Pharmacokinetics of zidovudine phosphorylation in human immunodeficiency virus-positive Thai patients and healthy volunteers|
Kesara Na Bangchang
Patrick G. Hoggard
Saye H. Khoo
Sara E. Gibbons
David J. Back
University of Liverpool
|Citation:||Antimicrobial Agents and Chemotherapy. Vol.44, No.7 (2000), 1986-1989|
|Abstract:||We assessed the pharmacokinetics of zidovudine (ZDV) in plasma and intracellular ZDV phosphate anabolites in peripheral blood mononuclear cells in Thai human immunodeficiency virus (HIV) type 1-infected patients and healthy volunteers. The plasma ZDV area under the concentration-time curve from 0 to 6 h (AUC0-6) was similar in patients and healthy volunteers (32.77 and 22.77 μmol/liter · h, respectively; confidence interval, -3.37 to 19.92). Although the concentration of ZDV triphosphate (ZDVTP) was similar in the two groups, the ZDV monophosphate (ZDVMP) AUC0-6 was significantly greater in HIV patients (1.12 pmol/106 cells) than in healthy volunteers (0.15 pmol/106 cells). In agreement with previously published data obtained with Caucasians, the significant difference in intracellular phosphorylation in Thai volunteers and HIV patients is primarily due to ZDVMP. Comparing the data from this study with the data obtained with Caucasians suggests no marked ethnic differences in ZDV phosphorylation.|
|Appears in Collections:||Scopus 1991-2000|
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