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Title: A double-blind placebo-controlled study of an infusion of lexipafant (platelet-activating factor receptor antagonist) in patients with severe sepsis
Authors: Yupin Suputtamongkol
Sunanta Intaranongpai
Michael D. Smith
Brian Angus
Wipada Chaowagul
Chairat Permpikul
Julie A. Simpson
Amorn Leelarasamee
Lloyd Curtis
Nicholas J. White
Mahidol University
Nuffield Department of Clinical Medicine
Sappasitthiprasong Hospital
British Bio-technology Ltd.
Surin Hospital
Taunton Hospital
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Mar-2000
Citation: Antimicrobial Agents and Chemotherapy. Vol.44, No.3 (2000), 693-696
Abstract: Platelet-activating factor (PAF) is a potent endogenous proinflammatory mediator implicated in the pathogenesis of septic shock. A double-blind randomized placebo-controlled trial of an intravenous PAF receptor antagonist (lexipafant) was conducted with 131 adult Thai patients with suspected severe sepsis (66 of whom had positive blood cultures). Detailed serial clinical, biochemical, and cytokine measurements were performed. Lexipafant treatment was well tolerated. The 28-day mortality in the lexipafant group (61.4%) was similar to that in the placebo group (62.6%). There was also no evidence that lexipafant affected clinical or biochemical measures of disease severity or the profile of sequentially measured plasma cytokine levels. PAF may not have an important role in the pathogenesis of severe sepsis.
ISSN: 00664804
Appears in Collections:Scopus 1991-2000

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