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Title: Thrombopoietin in Plasmodium falciparum malaria
Authors: Anna Kreil
Christoph Wenisch
Gary Brittenham
Sornchai Looareesuwan
Markus Peck-Radosavljevic
Universitat Wien
Karl-Franzens-Universitat Graz
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-2000
Citation: British Journal of Haematology. Vol.109, No.3 (2000), 534-536
Abstract: Thrombopoietin (TPO) is the key growth factor for platelet production and is elevated in states of platelet depletion. As thrombocytopenia is a common finding in malaria, we analysed TPO regulation before, during and after antimalarial treatment. Before treatment, TPO serum levels were significantly higher in patients with severe malaria (n = 35) than in patients with uncomplicated malaria (n = 44; P = 0.024), normalizing within 14-21 d of therapy. The rapid normalization of TPO levels and increase in low peripheral platelet counts after treatment indicate that the biosynthesis of TPO and its regulation in malaria patients are normal.
ISSN: 00071048
Appears in Collections:Scopus 1991-2000

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