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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/26354
Title: Mutations in a potassium channel (Kir2.6) causes susceptibility to thyrotoxic hypokalemic periodic paralysis
Authors: Devon P. Ryan
Magnus R. Dias da Silva
Tuck Wah Soong
Bertrand Fontaine
Matt R. Donaldson
Annie W.C. Kung
Wallaya Jongjaroenprasert
Mui Cheng Liang
Daphne Hc Khoo
Jin Seng Cheah
Su Chin Ho
Harold S. Bernstein
Rui M.B. Maciel
Robert H. Brown
Louis J. Ptáček
University of California, San Francisco
National Neuroscience Institute of Singapore
Inserm
The University of Hong Kong
Mahidol University
Yong Loo Lin School of Medicine
Singapore General Hospital
Universidade Federal de Sao Paulo
Massachusetts General Hospital
Keywords: Medicine
Issue Date: 1-Jan-2000
Citation: Qatar Medical Journal. Vol.9, No.2 (2000), 70-72
Abstract: Hypolalemic periodic paralysis is an uncommon complication of thyrotoxicosis. It usually affects men of Oriental origin and presents with acute and profound muscle weakness especially of the lower extremities. We report a 46 year old man from Kuwait with sudden paralysis of both legs. Physical examination showed signs of thyrotoxicosis and laboratory tests revealed severe hypokalemia, very low serum thyroid-stimulating hormone and very high free thyroxin. The motor deficit regressed within 8 hours of 80 mmol of KCI infusion. Awareness of such a problem is essential to avoid life threatening cardiac arrhythmia. Once recognized the treatment is simple and the prognosis is excellent.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85003601773&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/26354
ISSN: 02538253
Appears in Collections:Scopus 1991-2000

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