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Title: Inactivation of artemisinin by thalassemic erythrocytes
Authors: Juree Charoenteeraboon
Sumalee Kamchonwongpaisan
Prapon Wilairat
Phantip Vattanaviboon
Yongyuth Yuthavong
Mahidol University
Thailand National Science and Technology Development Agency
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jun-2000
Citation: Biochemical Pharmacology. Vol.59, No.11 (2000), 1337-1344
Abstract: Plasmodium falciparum infecting α-thalassemic erythrocytes (Hb H or Hb H/Hb Constant Spring) is resistant to artemisinin derivatives. Similar resistance, albeit at a much lower level, is shown by the parasite infecting β-thalassemia/Hb E erythrocytes. The resistance is due to host-specific factors, one of which is the higher uptake of the drugs by thalassemic erythrocytes than normal erythrocytes, due to binding with Hb H. In addition to higher drug binding, incubation of artemisinin with α-thalassemic erythrocytes resulted in preferential inactivation of the drug. Both thalassemic and normal erythrocytes have the capability to inactivate the drug. Addition of serum can protect against inactivation by normal erythrocytes, but not by thalassemic erythrocytes. Incubation with either the hemolysate or the membrane fraction from these erythrocytes also resulted in preferential inactivation of the drug. The drug was also inactivated by purified Hb H. It is concluded that the ineffectiveness of artemisinin derivatives against P. falciparum infecting thalassemic erythrocytes is due partly to competition of the host cell components for binding with the drugs, and partly to inactivation of the drugs by the cell components. (C) 2000 Elsevier Science Inc.
ISSN: 00062952
Appears in Collections:Scopus 1991-2000

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