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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/26365
Title: Effect of artemisinin on lipid peroxidation and fluidity of the erythrocyte membrane in malaria
Authors: Nathawut Sibmooh
Busaba Pipitaporn
Polrat Wilairatana
Jeerawan Dangdoungjai
Rachanee Udomsangpetch
Sornchai Looareesuwan
Udom Chantharaksri
Mahidol University
Rangsit University
Chulabhorn Research Institute
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2000
Citation: Biological and Pharmaceutical Bulletin. Vol.23, No.11 (2000), 1275-1280
Abstract: The effect of artemisinin on membrane fluidity of erythrocytes was investigated using spin labeling compounds, doxyl stearic acids. The membrane fluidity of erythrocytes from the in vitro culture and malaria patients was determined. In vitro, the erythrocytes in parasite culture showed an increase in membrane fluidity which was associated with the parasite counts and stage of parasites. Artemisinin caused reduction in membrane fluidity and the effect was more pronounced in the erythrocytes infected with schizont stage-parasites. In vivo, the elevation of plasma TBARs (thiobarbituric acid reactive substances) and reduction of membrane fluidity were evident in Plasmodium falciparum-infected patients, particularly in severe cases. The levels of plasma TBARs were related to the severity of the disease. Treatment with artemisinin alone showed no effect on plasma TBARs, and did not alter the membrane fluidity. Desferrioxamine, however, reduced oxidative damage during the infection without compromising the therapeutic effect of artemisinin. These findings suggested that the infected erythrocytes were prone to the effect of artemisinin. Addition of a chelator such as desferrioxamine is beneficial and can improve the treatment of severe malaria.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033671980&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/26365
ISSN: 09186158
Appears in Collections:Scopus 1991-2000

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