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dc.contributor.authorSaengtong Pongjaroenkiten_US
dc.contributor.authorKanya Jirajaroenraten_US
dc.contributor.authorChanikarn Boonchauyen_US
dc.contributor.authorUmnaj Chanamaen_US
dc.contributor.authorSomphob Leetachewaen_US
dc.contributor.authorLa aied Prapanthadaraen_US
dc.contributor.authorAlbert J. Kettermanen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThe Institute of Science and Technology for Research and Development, Mahidol Universityen_US
dc.contributor.otherChiang Mai Universityen_US
dc.identifier.citationInsect Biochemistry and Molecular Biology. Vol.31, No.1 (2001), 75-85en_US
dc.description.abstractThe genomic DNA of a GST class I alternative splicing gene has been characterized from Anopheles dirus, a Thai malaria vector. This gene organization is highly conserved in An. dirus and Anopheles gambiae (aggstlα), with >80% nucleotide identity in the coding region. Their gene organization contains six exons for four mature GST transcripts, which share exon 1 and exon 2 but vary between four different exon 3 sequences (exon 3A-3D). The deduced amino acid sequence of the GST transcripts from these two genes also shows very high conservation, with 85-93% identity for each orthologous gene. Two putative promoters and possible regulatory elements were predicted by a combination of the TSSW and MatInspector programs. The Ad214 promoter is proposed to be involved in developmental stage regulation. The Ad2112 promoter would appear to respond to intra- or extracellular stimuli. These two Anopheline species appear to have diverged in the distant past based on gene neighbors and phylogenetic data, yet these GST genes are still conserved. Therefore it is highly probable that this GST gene organization has one or more important roles. © 2001 Elsevier Science Ltd.en_US
dc.rightsMahidol Universityen_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleGenomic organization and putative promoters of highly conserved glutathione S-transferases originating by alternative splicing in Anopheles dirusen_US
Appears in Collections:Scopus 2001-2005

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