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Title: Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex
Authors: S. Boonphong
P. Kittakoop
M. Isaka
D. Pittayakhajonwut
M. Tanticharoen
Y. Thebtaranonth
Naresuan University
Thailand National Center for Genetic Engineering and Biotechnology
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 20-Aug-2001
Citation: Journal of Natural Products. Vol.64, No.7 (2001), 965-967
Abstract: Two new 10-membered lactones, namely, multiplolides A (1) and B (2), were isolated from the broth extract of the fungus Xylaria multiplex BCC 1111. Chemical structures of 1 and 2 were elucidated on the basis of their spectral data. Multiplolides A (1) and B (2) exhibited antifungal activity against Candida albicans with IC50 values of 7 and 2 μg/mL, respectively. Both 1 and 2 were inactive in the screening systems toward the malarial parasite Plasmodium falciparum (at 20 μg/mL) and were not cytotoxic to BC-1 and KB cell lines (at 20 μg/mL).
ISSN: 01633864
Appears in Collections:Scopus 2001-2005

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