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|Title:||Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex|
Thailand National Center for Genetic Engineering and Biotechnology
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Journal of Natural Products. Vol.64, No.7 (2001), 965-967|
|Abstract:||Two new 10-membered lactones, namely, multiplolides A (1) and B (2), were isolated from the broth extract of the fungus Xylaria multiplex BCC 1111. Chemical structures of 1 and 2 were elucidated on the basis of their spectral data. Multiplolides A (1) and B (2) exhibited antifungal activity against Candida albicans with IC50 values of 7 and 2 μg/mL, respectively. Both 1 and 2 were inactive in the screening systems toward the malarial parasite Plasmodium falciparum (at 20 μg/mL) and were not cytotoxic to BC-1 and KB cell lines (at 20 μg/mL).|
|Appears in Collections:||Scopus 2001-2005|
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