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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/26454
Title: Antimalarial halorosellinic acid from the marine fungus Halorosellinia oceanica
Authors: Maneekarn Chinworrungsee
Prasat Kittakoop
Masahiko Isaka
Amporn Rungrod
Morakot Tanticharoen
Yodhathai Thebtaranonth
Mahidol University
Thailand National Center for Genetic Engineering and Biotechnology
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 6-Aug-2001
Citation: Bioorganic and Medicinal Chemistry Letters. Vol.11, No.15 (2001), 1965-1969
Abstract: Three known compounds, 2-hexylidene-3-methylsuccinic acid (1), cytochalasin Q (2), and 5-carboxymellein (3), together with two new derivatives, 2-hexylidene-3-methylsuccinic acid 4-methyl ester (4) and an ophiobolane sesterterpene named halorosellinic acid (5), were isolated from culture broth of the marine fungus Halorosellinia oceanica BCC 5149. Compounds 1-3 exhibited moderate cytotoxicity against KB and BC-1 cell lines with IC50values of 1-13 μg/mL, while compounds 2, 3, 5, and 6 showed antimalarial activity with respective IC50values of 17, 4, 13, and 19 μg/mL. Halorosellinic acid (5) possessed only weak antimycobacterial activity with the minimum inhibitory concentration of 200 μg/mL. © 2001 Elsevier Science Ltd. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0035817392&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/26454
ISSN: 0960894X
Appears in Collections:Scopus 2001-2005

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