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Title: Structural basis for selectivity and toxicity of ribosomal antibiotics
Authors: Erik C. Böttger
Burkhard Springer
Therdsak Prammananan
Yishak Kidan
Peter Sander
Medizinische Hochschule Hannover (MHH)
ETH Zurich
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 15-May-2001
Citation: EMBO Reports. Vol.2, No.4 (2001), 318-323
Abstract: Ribosomal antibiotics must discriminate between bacterial and eukaryotic ribosomes to various extents. Despite major differences in bacterial and eukaryotic ribosome structure, a single nucleotide or amino acid determines the selectivity of drugs affecting protein synthesis. Analysis of resistance mutations in bacteria allows the prediction of whether cytoplasmic or mitochondrial ribosomes in eukaryotic cells will be sensitive to the drug. This has important implications for drug specificity and toxicity. Together with recent data on the structure of ribosomal subunits these data provide the basis for development of new ribosomal antibiotics by rationale drug design.
ISSN: 1469221X
Appears in Collections:Scopus 2001-2005

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