Please use this identifier to cite or link to this item:
|Title:||Structural basis for selectivity and toxicity of ribosomal antibiotics|
|Authors:||Erik C. Böttger|
Medizinische Hochschule Hannover (MHH)
|Keywords:||Biochemistry, Genetics and Molecular Biology|
|Citation:||EMBO Reports. Vol.2, No.4 (2001), 318-323|
|Abstract:||Ribosomal antibiotics must discriminate between bacterial and eukaryotic ribosomes to various extents. Despite major differences in bacterial and eukaryotic ribosome structure, a single nucleotide or amino acid determines the selectivity of drugs affecting protein synthesis. Analysis of resistance mutations in bacteria allows the prediction of whether cytoplasmic or mitochondrial ribosomes in eukaryotic cells will be sensitive to the drug. This has important implications for drug specificity and toxicity. Together with recent data on the structure of ribosomal subunits these data provide the basis for development of new ribosomal antibiotics by rationale drug design.|
|Appears in Collections:||Scopus 2001-2005|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.