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Title: Inhibition by vitamin E of cholangiocarcinoma induction due to combined nitrite and aminopyrine
Authors: Witaya Thamavit
Pakasit Pratoomtone
Surapol Kongtim
Tomoyuki Shirai
Nobuyuki Ito
Mahidol University
Nagoya City University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-2001
Citation: Asian Pacific Journal of Cancer Prevention. Vol.2, No.1 (2001), 69-70
Abstract: The present experiment was conducted to assess the influence of vitamin E, given in the diet at 0.5 or 1%, on induction of lesions in the Syrian hamster liver by long term combined administration of sodium nitrite and aminopyrine in the drinking water. Inhibition of both cholangiofibrosis and cholangiocarcinoma development, as well as a reduction in hepatocellular nodules was the result. The underlying mechanisms presumably involve alteration of endogenous dimethylnitrosamine formation by the vitamin, with clear implications for prevention in the human environment.
ISSN: 2476762X
Appears in Collections:Scopus 2001-2005

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