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Title: Toxoplasma gondii antibodies in HIV and non-HIV infected Thai pregnant women
Authors: Darawan Wanachiwanawin
Ruengpung Sutthent
Kulkanya Chokephaibulkit
Vanna Mahakittikun
Jeerawan Ongrotchanakun
Nantiya Monkong
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Dec-2001
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.19, No.4 (2001), 291-293
Abstract: Serological evidence for Toxoplasma gondii infection in Thai pregnant women was investigated. One thousand six hundred and sixtynine blood specimens were collected from 838 HIV-seropositive and 831 HIV-seronegative pregnant women attending the antenatal-care clinic at Siriraj Hospital, Bangkok, Thailand, during a two-year period. Toxoplasma IgG antibody was detected, using a solid-phase enzyme-linked immunosorbent assay in which the membrane protein p-30 was the predominant antigen. IgG positive sera were subsequently examined for IgM antibody by the capture antibody enzyme immunoassay. The IgG antibody was found in 450 (53.7%) HIV seropositive women and 44 (5.3%) non-HIV infected women, with a statistically significant difference (p < 0.0001). Three of the 450 HIV-seropositive and 2 of the 44 HIV-seronegative sera with IgG antibody were positive for IgM antibody against T. gondii. This result suggested that HIV seropositive pregnant women had a higher risk of Toxoplasma infection with increase exposure to their offspring.
ISSN: 0125877X
Appears in Collections:Scopus 2001-2005

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