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Title: Survey of reverse transcriptase from the heterosexual epidemic of human immunodeficiency virus type 1 CRF01_AE in Thailand from 1990 to 2000
Authors: Sunee Sirivichayakul
Wasan Chantratita
Ruengpung Sutthent
Kiat Ruxrungtham
Praphan Phanuphak
Robert B. Oelrichs
Chulalongkorn University
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Mahidol University
Thai Red Cross AIDS Research Centre
Macfarlane Burnet Institute for Medical Research
Keywords: Immunology and Microbiology;Medicine
Issue Date: 20-Jul-2001
Citation: AIDS Research and Human Retroviruses. Vol.17, No.11 (2001), 1077-1081
Abstract: Genetic diversity of the HIV-1 envelope gene has shown a steady increase over time in the Thai and other regional epidemics. A serial survey of subtype CRF01_AE polymerase gene (RT) diversity in Thailand was performed, using 48 novel and 15 reported sequences covering the period 1990-2000. These sequences were gathered from individuals whose sole risk factor for infection was heterosexual contact. By contrast to envelope, diversity was low and, despite a 40% increase early in the epidemic, has remained static since 1996. These results indicate that epidemic HIV-1 may be constrained within defined limits of genetic diversity at least in some genomic regions. © 2001 Mary Ann Liebert, Inc.
ISSN: 08892229
Appears in Collections:Scopus 2001-2005

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