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Title: Case-control studies on host factors in severe malaria
Authors: Mathieu Nacher
Pratap Singhasivanon
Frédérick Gay
Udomsak Silachamroon
Sornchai Looareesuwan
Faculte de Medecine Pierre et Marie Curie
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 4-Jul-2001
Citation: Trends in Parasitology. Vol.17, No.6 (2001), 253-254
Abstract: Although molecular biology has illustrated the phenotypic heterogeneity of Plasmodium falciparum, there are still no specific markers of virulence. As parasite virulence is an important determinant of severe malaria, the choice of comparison groups in the study of host factors influencing severity is a delicate issue. Ignoring parasite factors in the selection of controls potentially leads to biased comparisons between a majority of cases with virulent parasites and a majority of controls with non-virulent parasites. This article discusses how to avoid this virulence bias in the absence of specific markers of virulence.
ISSN: 14714922
Appears in Collections:Scopus 2001-2005

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