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Title: Antibodies specific for heat shock proteins in human and murine malaria
Authors: Manxin Zhang
Hajime Hisaeda
Shigeyuki Kano
Yoshitsugu Matsumoto
Yan Peng Hao
Sornchai Looaresuwan
Masamichi Aikawa
Kunisuke Himeno
Tokushima University Faculty of Medicine
Gunma University Faculty of Medicine
University of Tokyo
Mahidol University
Tokai University School of Medicine
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Apr-2001
Citation: Microbes and Infection. Vol.3, No.5 (2001), 363-367
Abstract: Heat shock proteins (HSPs) are immunodominant antigens recognized by the host immune system in various infectious diseases. We analyzed HSP-specific antibodies, including immunoglobulin G (IgG), IgM and IgA, in sera from malaria patients in Thailand by using an enzyme-linked immunosorbent assay. All of the antibodies to HSP90 were remarkably increased in the patients compared with those in controls, while only IgM to HSP70 or IgA to HSP65 was significantly elevated. Further experiments showed that anti-HSP IgG was significantly increased in C57BL/6 mice infected with a non-lethal strain of Plasmodium yoelii, with anti-HSP90 IgG being the most elevated. These results suggest that the antigenic potential of HSP90 is higher than those of HSP70 and HSP65 in malaria infection. © 2001 Éditions scientifiques et médicales Elsevier SAS.
ISSN: 12864579
Appears in Collections:Scopus 2001-2005

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