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|Title:||Antibodies specific for heat shock proteins in human and murine malaria|
Yan Peng Hao
Tokushima University Faculty of Medicine
Gunma University Faculty of Medicine
University of Tokyo
Tokai University School of Medicine
|Keywords:||Immunology and Microbiology;Medicine|
|Citation:||Microbes and Infection. Vol.3, No.5 (2001), 363-367|
|Abstract:||Heat shock proteins (HSPs) are immunodominant antigens recognized by the host immune system in various infectious diseases. We analyzed HSP-specific antibodies, including immunoglobulin G (IgG), IgM and IgA, in sera from malaria patients in Thailand by using an enzyme-linked immunosorbent assay. All of the antibodies to HSP90 were remarkably increased in the patients compared with those in controls, while only IgM to HSP70 or IgA to HSP65 was significantly elevated. Further experiments showed that anti-HSP IgG was significantly increased in C57BL/6 mice infected with a non-lethal strain of Plasmodium yoelii, with anti-HSP90 IgG being the most elevated. These results suggest that the antigenic potential of HSP90 is higher than those of HSP70 and HSP65 in malaria infection. © 2001 Éditions scientifiques et médicales Elsevier SAS.|
|Appears in Collections:||Scopus 2001-2005|
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