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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/26576
Title: Identification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria
Authors: M. Mayxay
S. Pukrittayakamee
K. Chotivanich
M. Imwong
S. Looareesuwan
N. J. White
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2001
Citation: American Journal of Tropical Medicine and Hygiene. Vol.65, No.5 (2001), 588-592
Abstract: In Thailand, ∼ 8% of patients treated for vivax malaria are found subsequently to have coinfection with Plasimodium falciparum. A P. falciparum histidine rich protein 2 (PfHRP-2) dipstick test was evaluated as a predictor of mixed infections with subpatent P. falciparum in a prospective study of 238 patients admitted to the hospital with acute vivax malaria. Of these, 23 (10%) had subsequent development of falciparum malaria without reexposure. Patients with cryptic P. falciparum infection had a significantly lower mean (standard deviation) hematocrit than those with P. vivax alone: 29.6 (7.6%) versus 37.2 (6.4%) (P < 0.0001). Using microscopic appearance of P. falciparum after the start of treatment as the reference standard, the PfHRP-2 test was 74% sensitive and 99% specific in predicting mixed infections with subpatent P. falciparum parasitemia at presentation. The PfHRP-2 dipstick test may be a useful adjunct to microscopy in areas where mixed infections are common.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0035208108&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/26576
ISSN: 00029637
Appears in Collections:Scopus 2001-2005

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