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Title: Association of hepatomegaly and jaundice with acute renal failure but not with cerebral malaria in severe falciparum malaria in Thailand
Authors: M. Nacher
S. Treeprasertsuk
P. Singhasivanon
U. Silachamroon
S. Vannaphan
F. Gay
S. Looareesuwan
P. Wilairatana
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2001
Citation: American Journal of Tropical Medicine and Hygiene. Vol.65, No.6 (2001), 828-833
Abstract: We conducted a case record study comparing liver tests abnormalities in 20 malaria-related acute renal failure cases without cerebral malaria, 52 cerebral malaria cases without other organ impairment, 189 cases of non-severe malaria associated with a high parasite burden, and 131 cases of mild Plasmodium falciparum malaria. Jaundice and hepatomegaly were significantly associated with renal failure (adjusted odds ratio [AOR], 3.3, 95% confidence interval [CI], 1.3-8.6, P = 0.01; and AOR, 1.7 95% CI, 1.13-2.4, P = 0.01) but not with cerebral malaria (AOR, 1, 95% CI, 0.5-2, P = 0.8; and AOR, 1.08, 95% CI, 0.8-1.8, P = 0.5). Patients with acute renal failure were significantly older and had increased liver abnormalities compared with other groups. Although an increase in the proportion of mature schizonts over ring forms was significantly associated with cerebral malaria, it did not seem to have affected acute renal failure. These results suggested that cytoadherence was not the main determinant for renal failure and that jaundice itself may have potentiated the effects of hypovolemia.
ISSN: 00029637
Appears in Collections:Scopus 2001-2005

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