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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/26580
Title: Association of splenomegaly with cerebral malaria and decreased concentrations of reactive nitrogen intermediates in Thailand
Authors: M. Nacher
P. Singhasivanon
S. Treeprasertsuk
Y. Chantachum
S. Vannaphan
B. Traore
F. Gay
S. Looareesuwan
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2001
Citation: American Journal of Tropical Medicine and Hygiene. Vol.65, No.5 (2001), 639-643
Abstract: The role of the spleen during Plasmodium falciparum malaria in humans is unclear. In Thailand, malaria transmission is low and splenomegaly is rarer than in high transmission areas. We compared the prevalence of splenomegaly between 52 cerebral malaria patients and 191 patients without complications despite a high parasite biomass. We also measured concentrations of reactive nitrogen intermediates (RNIs) in a fraction of these cases recruited in 1998 (24 cerebral malaria and 56 controls). Splenomegaly was significantly associated with cerebral malaria (adjusted odds ratio = 2.07 [95% confidence interval = 1-4.2]; P = 0.048). There was a linear trend for this association (P = 0.0003). After adjusting for potential confounders, concentrations of RNIs were significantly lower in the presence of splenomegaly (P = 0.01). These results suggest that in humans, as in animal models, the spleen may be involved in the pathogenesis of cerebral malaria. The relationship between RNI concentrations and the spleen suggest that nitric oxide may have a regulating role in the complex physiology of the spleen during malaria.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0035215368&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/26580
ISSN: 00029637
Appears in Collections:Scopus 2001-2005

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