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dc.contributor.authorUrai Chaisrien_US
dc.contributor.authorMichio Nagataen_US
dc.contributor.authorHisao Kurazonoen_US
dc.contributor.authorHiroshi Horieen_US
dc.contributor.authorPongsri Tongtaween_US
dc.contributor.authorHideo Hayashien_US
dc.contributor.authorTeruo Watanabeen_US
dc.contributor.authorPramuan Tapchaisrien_US
dc.contributor.authorManas Chongsa-Nguanen_US
dc.contributor.authorWanpen Chaicumpaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Tsukubaen_US
dc.contributor.otherOkayama Universityen_US
dc.contributor.otherChiba Children's Hospitalen_US
dc.identifier.citationMicrobial Pathogenesis. Vol.31, No.2 (2001), 59-67en_US
dc.description.abstractHaemolytic uraemic syndrome (HUS) is characterized by haemolytic anaemia, thrombocytopenia and renal failure. Infection with enterohaemorrhagic Escherichia coli (EHEC), mainly O157:H7, has been strongly implicated as the major cause of HUS in children. The pathogenesis of HUS caused by the infection is not well understood and the defined sites of Stx in kidney of EHEC-infected humans has not been clearly demonstrated. The aim of this study was to investigate and compare the locations of Stx deposition in kidneys of paediatric and geriatric patients who died from enterohaemorrhagic E. coli O157 (EHEC) associated HUS, using an immunoperoxidase staining of the tissues. The study revealed that binding of Stx was relatively less and limited only to the renal tubules of an adult case (81 years old), while more binding was found at both renal tubules and glomeruli of an infant case (21 months old). The Stx binding in the infant's glomeruli was at podocytes, mesangial and endothelial cells. It has been known that young children are more susceptible than adults to HUS. One possibility for this is that the more extensive binding of the Stx to the kidney tissue of the paediatric patient might be due to the higher synthesis and expression of Stx receptors, i.e. Gb3, in infants and less so in the aged individuals. However, other alternatives are possible, for example, the difference in stage of HUS in individual patients. Thus it is too early to draw any conclusion on this enigma and further investigation is required. © 2001 Academic Press.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleLocalization of Shiga toxins of enterohaemorrhagic Escherichia coli in kidneys of paediatric and geriatric patients with fatal haemolytic uraemic syndromeen_US
Appears in Collections:Scopus 2001-2005

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