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dc.contributor.authorPravit Akarasereenonten_US
dc.contributor.authorTeonchit Nuamchiten_US
dc.contributor.authorAthiwat Thawornen_US
dc.contributor.authorWattana Leowattanaen_US
dc.contributor.authorSirikul Chotewuttakornen_US
dc.contributor.authorPanya Khunawaten_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-09-07T09:44:01Z-
dc.date.available2018-09-07T09:44:01Z-
dc.date.issued2001-12-01en_US
dc.identifier.citationJournal of the Medical Association of Thailand. Vol.84, No.SUPPL. 3 (2001)en_US
dc.identifier.issn01252208en_US
dc.identifier.other2-s2.0-0347811268en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0347811268&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/26636-
dc.description.abstractNitric oxide (NO) plays a pivotal role in the pathophysiology of coronary artery disease. The roles of NO are not only physiological but also pathological in the cardiovascular system. An inappropriate release of NO has been linked to the pathogenesis of CAD. The authors investigated whether serum NOx (nitrate and nitrite), a stable end product of NO, level was related to patients with coronary artery disease. The blood chemistry, such as cholesterol, triglyceride, LDL-C, HDL-C and blood sugar, was also measured in comparison with serum NOx. Serum NOx was measured in samples from 20 healthy controls, 20 angina patients without angiographic evidence of coronary lesions (CAG) and 20 angina patients with angiographic evidence of coronary lesions (CAD) by using modified Griess reaction. The mean serum NOx levels in the CAD groups was higher than CAG and control groups (41.3 ± 5.5, 32.7 ± 3.9 and 25.7 ± 3.5 μmol/L, respectively). NOx levels in the CAD group was only significantly higher than the control groups (p < 0.05) but not the CAG groups. There were no significant differences of NOx levels in all age groups. In the CAD group, women showed significantly higher NOx levels than men (64.0 ± 7.5 and 29.0 ± 4.7 μmol/L, respectively, p < 0.05). Interestingly, the- mean serum NOx levels in the CAD groups was significantly higher in a group of abnormal lipid profiles (cholesterol, triglyceride, LDL-C) and blood sugar than in a group of normal profiles. The results suggested that there was an increased NOx levels in patients with coronary artery disease and much higher in patients with multiple underlying conditions such as hyperlipidemia and hyperglycemia. Thus, the measurement of the NOx levels at different times may help to monitor the state and severity of coronary artery disease.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0347811268&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleSerum nitric oxide levels in patients with coronary artery diseaseen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
Appears in Collections:Scopus 2001-2005

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