Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAdisak Wongkajornsilpen_US
dc.contributor.authorMongkol Ouyprasertkulen_US
dc.contributor.authorTumtip Sangruchien_US
dc.contributor.authorSukit Huabpraserten_US
dc.contributor.authorYuexin Panen_US
dc.contributor.authorNantasak Tisavipaten_US
dc.contributor.authorVoravut Chanyavanichen_US
dc.contributor.authorSupatra Sangruchien_US
dc.contributor.authorKaruna Chomsamuten_US
dc.contributor.authorDonald D. Anthonyen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherCase Western Reserve Universityen_US
dc.identifier.citationJournal of the Medical Association of Thailand. Vol.84, No.SUPPL. 3 (2001)en_US
dc.description.abstractA subject inflicted with glioblastoma multiforme who received partial tumor resection and radiotherapy was recruited for an ex vivo gene therapy protocol using irradiated autologous tumor cells that had been engineered to suppress the expression of insulin-like growth factor I as the tumor vaccine. After subcutaneous injection for 8 weeks, the subject developed peri-tumor necrosis with mass effect. The authors wondered whether this event could have resulted from the tumor vaccine. The tissue section bordering the necrotic tumor tissue to the viable normal tissue was examined for nature of any infiltrated cells and their activities. Lymphocytes, macrophages, and a small number of neutrophils diffused into the necrotic tumor tissue were found. The infiltrated lymphocytes consisted of both CD4+ and CD8+ T cells. The functional activity of these lymphocytes was demonstrated by the active production of interferon γ and tumor necrosis factor α based on the respective immunofluorescent staining localized to these cells. This finding is compatible with the proposed mechanism underlying the tumor vaccination. However, the contribution of radiation treatment to this event cannot be clearly ruled out.en_US
dc.rightsMahidol Universityen_US
dc.titleThe analysis of peri-tumor necrosis following the subcutaneous implantation of autologous tumor cells transfected with an episome transcribing an antisense insulin-like growth factor 1 RNA in a glioblastoma multiforme subjecten_US
Appears in Collections:Scopus 2001-2005

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.