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Title: Fake artesunate in southeast Asia
Authors: Paul Newton
Stephane Proux
Michael Green
Frank Smithuis
Jan Rozendaal
Sompol Prakongpan
Kesinee Chotivanich
Mayfong Mayxay
Sornchai Looareesuwan
Jeremy Farrar
Francois Nosten
Nicholas J. White
Mahidol University
John Radcliffe Hospital
Shoklo Malaria Research Unit
Centers for Disease Control and Prevention
M├ędecins Sans Frontieres (Netherlands)
Centre for Tropical Diseases Vietnam
European Commission/Cambodia Malaria Control Project
Keywords: Medicine
Issue Date: 16-Jun-2001
Citation: Lancet. Vol.357, No.9272 (2001), 1948-1950
Abstract: Artesunate is a key antimalarial drug in the treatment of multidrug-resistant Plasmodium falciparum malaria in southeast Asia. We investigated the distribution of counterfeit artesunate tablets by use of the validated, simple, and inexpensive Fast Red TR dye technique. We also aimed to identify distinguishing characteristics of the fake drugs. Of 104 shop-bought "artesunate" samples from Cambodia, Laos, Myanmar (Burma), Thailand, and Vietnam, 38% did not contain artesunate. Characteristics such as cost and physical appearance of the tablets and packaging reliably predicted authenticity. The illicit trade in counterfeit antimalarials is a great threat to the lives of patients with malaria. The dye test will assist national malaria control authorities in urgently needed campaigns to stop this murderous trade.
ISSN: 01406736
Appears in Collections:Scopus 2001-2005

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