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Title: A comparative trial of albendazole alone versus combination of albendazole and praziquantel for treatment of Trichuris trichiura infection
Authors: Chukiat Sirivichayakul
Chanathep Pojjaroen-anant
Pataraporn Wisetsing
Pornthep Chanthavanich
Rangson Praevanit
Kriengsak Limkittikul
Krisana Pengsaa
Mahidol University
Keywords: Medicine
Issue Date: 1-Jun-2001
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.32, No.2 (2001), 297-301
Abstract: A randomized clinical trial was conducted to compare the effectiveness of albendazole alone and albendazole combined with praziquantel in the treatment of Trichuris trichiura infection. The drug regimens consisted of single dose of albendazole 400 mg (Al, n=34), 3 days of albendazole 400 mg daily (A3, n=34), 5 days of albendazole 400 mg daily (A5, n=35), single dose of albendazole 400 mg plus praziquantel 40 mg/kg (A1P1, n=34), and 3 days of albendazole 400 mg plus praziquantel 40 mg/kg daily (A3P3, n=36). It was found that treatment with 3 or more consecutive days of albendazole with or without praziquantel resulted in a significant reduction in density of Trichuris eggs in stools while a single dose of such drug did not. Praziquantel was not shown to have synergistic or antagonistic effects with albendazole. A regimen of 400 mg of albendazole daily for 3 days was found to be the most suitable therapy for Trichuris infection.
ISSN: 01251562
Appears in Collections:Scopus 2001-2005

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