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Title: Clinical trial of halofantrine with modified doses for treatment of malaria in the hospital for tropical diseases
Authors: Srivicha Krudsood
Pratap Singhasivanon
Udomsak Silachamroon
Sombat Treeprasertsuk
Wongphan Kaivipakbanyai
Kobsiri Chalermrut
Nuntaporn Phophak
John Horton
Dennis Kyle
Sornchai Looareesuwan
Mahidol University
GlaxoSmithKline plc.
Armed Forces Research Institute of Medical Sciences, Thailand
Keywords: Medicine
Issue Date: 1-Jun-2001
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.32, No.2 (2001), 255-261
Abstract: The spread of falciparum malaria resistant to chloroquine all over Southeast Asian continent has led to increasing use of alternative antimalarial drugs. Halofantrine has been shown to be effective against multidrug resistant Plasmodium falciparum. One hundred and twenty falciparum malaria cases were randomly assigned to one of three different halofantrine regimes. Group I (HA1) received 500 mg three times daily for 3 days (total dose: 4,500 mg), group II (HA2) received 500 mg three times daily for the first and the third day (total dose: 3,000 mg) and group III (HA3) received 500 mg three times for one day followed by 500 mg once daily for 7 days (total dose: 4,500 mg). No significant difference in the cure rate was observed among the three regimes (cure rate: 89%, 73%, 97% respectively). However, the cure rate was significantly higher in the HA3 group when compared to the HA2 group. There were no overt cardiac problems seen in this study. Thus, halofantrine has high efficacy in the recommended treatment dose of 500 mg three times after meals on the first day followed by 500 mg once a day after a meal for 7 days (total dose: 4,500 mg).
ISSN: 01251562
Appears in Collections:Scopus 2001-2005

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