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dc.contributor.authorSrivicha Krudsooden_US
dc.contributor.authorPratap Singhasivanonen_US
dc.contributor.authorUdomsak Silachamroonen_US
dc.contributor.authorSombat Treeprasertsuken_US
dc.contributor.authorWongphan Kaivipakbanyaien_US
dc.contributor.authorKobsiri Chalermruten_US
dc.contributor.authorNuntaporn Phophaken_US
dc.contributor.authorJohn Hortonen_US
dc.contributor.authorDennis Kyleen_US
dc.contributor.authorSornchai Looareesuwanen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherGlaxoSmithKline plc.en_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciences, Thailanden_US
dc.identifier.citationSoutheast Asian Journal of Tropical Medicine and Public Health. Vol.32, No.2 (2001), 255-261en_US
dc.description.abstractThe spread of falciparum malaria resistant to chloroquine all over Southeast Asian continent has led to increasing use of alternative antimalarial drugs. Halofantrine has been shown to be effective against multidrug resistant Plasmodium falciparum. One hundred and twenty falciparum malaria cases were randomly assigned to one of three different halofantrine regimes. Group I (HA1) received 500 mg three times daily for 3 days (total dose: 4,500 mg), group II (HA2) received 500 mg three times daily for the first and the third day (total dose: 3,000 mg) and group III (HA3) received 500 mg three times for one day followed by 500 mg once daily for 7 days (total dose: 4,500 mg). No significant difference in the cure rate was observed among the three regimes (cure rate: 89%, 73%, 97% respectively). However, the cure rate was significantly higher in the HA3 group when compared to the HA2 group. There were no overt cardiac problems seen in this study. Thus, halofantrine has high efficacy in the recommended treatment dose of 500 mg three times after meals on the first day followed by 500 mg once a day after a meal for 7 days (total dose: 4,500 mg).en_US
dc.rightsMahidol Universityen_US
dc.titleClinical trial of halofantrine with modified doses for treatment of malaria in the hospital for tropical diseasesen_US
Appears in Collections:Scopus 2001-2005

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