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Title: Frequency of early rising parasitemia in falciparum malaria treated with artemisinin derivatives
Authors: Udomsak Silachamroon
Weerapong Phumratanaprapin
Srivicha Krudsood
Sombat Treeprasertsuk
Valai Budsaratid
Karnchana Pornpininworakij
Polrat Wilairatana
Sornchai Looareesuwan
Dept. of Clinical Tropical Medicine
Mahidol University
Keywords: Medicine
Issue Date: 1-Mar-2001
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.32, No.1 (2001), 50-56
Abstract: To define the frequency of the early rising of parasitemia in falciparum malaria patients treated with artemisinin derivatives, a retrospective chart review of 497 patients admitted to the Hospital for Tropical Diseases, Bangkok in 1996 was carried out. Early rising parasitemia, defined as an increase in the parasite count over the baseline pretreatment level during the first 24 hours of treatment, was found in 59/229 episodes (25.8%) of uncomplicated, and 111/268 episodes (41.3%) of complicated falciparum malaria. All uncomplicated cases were successfully treated without developing any complications. There were 2 deaths and 13 changes of drug regimen in the complicated group. Only one of these unfavorable responses was due to parasite response. Early rising parasitemia was very common in falciparum malaria treated with artemisinin derivatives, despite their ability to clear the parasitemia, and did not indicate failure of the drug used.
ISSN: 01251562
Appears in Collections:Scopus 2001-2005

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