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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/26846
Title: Phase II trial of paclitaxel, carboplatin, and concurrent radiation therapy for locally advanced non-small-cell lung cancer
Authors: Vorachai Ratanatharathorn
Vicharn Lorvidhaya
Savitree Maoleekoonpairoj
Pramook Phromratanapongse
Suwannee Sirilerttrakul
Puangthong Kraipiboon
Arkom Cheirsilpa
Saipin Tangkaratt
Vichien Srimuninnimit
Pitayapoon Pattaranutaporn
Mahidol University
Chiang Mai University
Pramongkutklao Hospital
National Cancer Institute Thailand
Keywords: Medicine
Issue Date: 10-Feb-2001
Citation: Lung Cancer. Vol.31, No.2-3 (2001), 257-265
Abstract: We conducted a phase II trial to investigate the efficacy of concurrent chemoradiation in patients with stage III non-small-cell lung cancer (NSCLC). Thirty patients with inoperable NSCLC were enrolled onto a multicenter phase II trial of concurrent chemoradiation therapy. Patients received six weekly cycles of paclitaxel 45 mg/m2over 1 h; carboplatin at (area under the curve) AUC 2; and radiation therapy of 60 Gy. Radiation was administered to the primary tumor and regional lymph nodes (40 Gy over 4 weeks) followed by a boost to the primary tumor (20 Gy in 2 weeks). After the initial phase of concurrent chemoradiation, patients received an additional four cycles of paclitaxel 175 mg/m2over 3 h and carboplatin at AUC 6 every 3 weeks. The overall objective response rate of 30 assessable patients was 76.7%. At the median follow-up time of 13.1 months, the median survival time was 14.5 months (95% CI, 10.59-18.48). The median progression-free survival was 10.5 months (95% CI, 7.72-13.28). The major toxicity was hematologic. The incidence of grade 3 esophagitis was 10%. In conclusion, this chemoradiation regimen is well tolerated and shows significant clinical results for locally advanced NSCLC. Locoregional failure rate remains an important issue with this newer chemotherapeutic regimen. A novel chemotherapy and radiation therapy is clearly needed. Copyright © 2001 Elsevier Science Ireland Ltd.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0035139474&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/26846
ISSN: 01695002
Appears in Collections:Scopus 2001-2005

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