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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/26871
Title: The effect of estradiol vaginal tablet and conjugated estrogen cream on urogenital symptoms in postmenopausal women: A comparative study
Authors: Jittima Manonai
Urusa Theppisai
Somsak Suthutvoravut
Umaporn Udomsubpayakul
Apichart Chittacharoen
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-2001
Citation: Journal of Obstetrics and Gynaecology Research. Vol.27, No.5 (2001), 255-260
Abstract: Objectives: To compare the effects of estradiol vaginal tablet with conjugated estrogen cream on urogenital symptoms, vaginal health index, vaginal cytology, endometrial thickness, and plasma estradiol level in postmenopausal women. Methods: Fifty-three women with urogenital symptoms were randomized to local vaginal treatment of 25 μg estradiol tablet or 1 g of conjugated estrogen cream for 12 weeks. They were assessed for urogenital symptoms, vaginal health index, vaginal cytology, endometrial thickness and estradiol level. Results: Forty-eight women completed the treatment. Both groups showed improvement of urogenital symptoms, vaginal health index, and vaginal cytology after the first 4 weeks of treatment. Conjugated estrogen cream showed superior efficacy in alleviating vaginal dryness and dyspareunia. Two cases of endometrial proliferation were noted. Conclusions: Estradiol vaginal tablet and conjugated estrogen cream were effective in treating urogenital symptoms, the restoration of normal vaginal epithelium and reduction of vaginal pH in postmenopausal women. However, 2 cases of endometrial proliferation were noted.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0035204045&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/26871
ISSN: 13418076
Appears in Collections:Scopus 2001-2005

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