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Title: An open, baseline controlled evaluation of sertraline safety and efficacy in the treatment of depression in Thai patients
Authors: Vudhichai Boonyanaruthee
Sudsabuy Chulakadabba
Vira Khuangsirikul
Thienchai Ngamthipwatthana
Benjaporn Panyayong
Pichai Saengcharnchai
Tinnakorn Chan-Ob
Suparat Ekasawin
Panpimol Lotrakul
Raviwan Nivataphan
Pairat Pruksachatkunakorn
Anant Thanaprasertgorn
Chiang Mai University
Mahidol University
Thailand Ministry of Public Health
Pramongkutklao Hospital
Chulalongkorn University
Taksin Hospital
Keywords: Medicine
Issue Date: 1-Jan-2001
Citation: Journal of the Medical Association of Thailand. Vol.84, No.1 (2001), 54-62
Abstract: An open, baseline controlled study of sertraline in depressed patients was conducted in 6 treatment sites. Eighty-two patients between 20-82 years of age with DSM III-R diagnosis of a depressive illness received sertraline 50-200 mg/day. Among evaluable patients, there was a significant reduction in depressive symptoms at the final visit. A statistically significant change from baseline in Montgomery Asberg Depression Rating Scale (MADRS), Hospital Anxiety Depression Rating Scale (HAD), and Clinical Global Impression Severity of Illness Scale (CGI-S) scores was demonstrated. On the basis of MADRS criterion, 96.0 per cent of patients responded and on the basis of CGI-S criterion, 86.6 per cent of patients responded. In 73.2 per cent of patients the final sertraline dosage was 50 mg. All-cause adverse events were recorded in 35 patients (42.7%), whereas 22 (26.8%) had adverse events that were judged treatment-related. The most frequently reported events were nausea and headache. Overall, the patients tolerated sertraline very well. The results of the study suggest that sertraline is an effective, well-tolerated and safe treatment for depression in Thai patients.
ISSN: 01252208
Appears in Collections:Scopus 2001-2005

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