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Title: Limited global diversity of the Plasmodium vivax merozoite surface protein 4 gene
Authors: Chaturong Putaporntip
Somchai Jongwutiwes
Marcelo U. Ferreira
Hiroji Kanbara
Rachanee Udomsangpetch
Liwang Cui
Chulalongkorn University
Universidade de Sao Paulo - USP
Nagasaki University
Mahidol University
Pennsylvania State University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 1-Sep-2009
Citation: Infection, Genetics and Evolution. Vol.9, No.5 (2009), 821-826
Abstract: Merozoite surface proteins (MSPs) of the malaria parasites are major candidates for vaccine development targeting asexual blood stages. However, the diverse antigenic repertoire of these antigens that induce strain-specific protective immunity in human is a major challenge for vaccine design and often determines the efficacy of a vaccine. Here we further assessed the genetic diversity of Plasmodium vivax MSP4 (PvMSP4) protein using 195 parasite samples collected mostly from Thailand, Indonesia and Brazil. Overall, PvMSP4 is highly conserved with only eight amino acid substitutions. The majority of the haplotype diversity was restricted to the two short tetrapeptide repeat arrays in exon 1 and 2, respectively. Selection and neutrality tests indicated that exon 1 and the entire coding region of PvMSP4 were under purifying selection. Despite the limited nucleotide polymorphism of PvMSP4, significant genetic differentiation among the three major parasite populations was detected. Moreover, microgeographical heterogeneity was also evident in the parasite populations from different endemic areas of Thailand. © 2009 Elsevier B.V. All rights reserved.
ISSN: 15671348
Appears in Collections:Scopus 2006-2010

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