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Title: Aromatase inhibitory, radical scavenging, and antioxidant activities of depsidones and diaryl ethers from the endophytic fungus Corynespora cassiicola L36
Authors: Porntep Chomcheon
Suthep Wiyakrutta
Nongluksna Sriubolmas
Nattaya Ngamrojanavanich
Surapong Kengtong
Chulabhorn Mahidol
Somsak Ruchirawat
Prasat Kittakoop
Chulabhorn Research Institute
Chulalongkorn University
Mahidol University
Center for Environmental Health
The Institute of Science and Technology for Research and Development, Mahidol University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Feb-2009
Citation: Phytochemistry. Vol.70, No.3 (2009), 407-413
Abstract: Isolation of a broth extract of the endophytic fungus Corynespora cassiicola L36 afforded three compounds, corynesidones A (1) and B (3), and corynether A (5), together with a known diaryl ether 7. Compounds 1, 3, 5, and 7 were relatively non-toxic against cancer cells, and inactive toward normal cell line, MRC-5. Corynesidone B (3) exhibited potent radical scavenging activity in the DPPH assay, whose activity was comparable to ascorbic acid. Based on the ORAC assay, compounds 1, 3, 5, and 7 showed potent antioxidant activity. However, the isolated natural substances and their methylated derivatives (1-8) neither inhibited superoxide anion radical formation in the XXO assay nor suppressed TPA-induced superoxide anion generation in HL-60 cell line. Corynesidone A (1) inhibited aromatase activity with an IC50value of 5.30 μM. © 2009 Elsevier Ltd. All rights reserved.
ISSN: 00319422
Appears in Collections:Scopus 2006-2010

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