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dc.contributor.authorPorntep Chomcheonen_US
dc.contributor.authorSuthep Wiyakruttaen_US
dc.contributor.authorNongluksna Sriubolmasen_US
dc.contributor.authorNattaya Ngamrojanavanichen_US
dc.contributor.authorSurapong Kengtongen_US
dc.contributor.authorChulabhorn Mahidolen_US
dc.contributor.authorSomsak Ruchirawaten_US
dc.contributor.authorPrasat Kittakoopen_US
dc.contributor.otherChulabhorn Research Instituteen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherCenter for Environmental Healthen_US
dc.contributor.otherThe Institute of Science and Technology for Research and Development, Mahidol Universityen_US
dc.identifier.citationPhytochemistry. Vol.70, No.3 (2009), 407-413en_US
dc.description.abstractIsolation of a broth extract of the endophytic fungus Corynespora cassiicola L36 afforded three compounds, corynesidones A (1) and B (3), and corynether A (5), together with a known diaryl ether 7. Compounds 1, 3, 5, and 7 were relatively non-toxic against cancer cells, and inactive toward normal cell line, MRC-5. Corynesidone B (3) exhibited potent radical scavenging activity in the DPPH assay, whose activity was comparable to ascorbic acid. Based on the ORAC assay, compounds 1, 3, 5, and 7 showed potent antioxidant activity. However, the isolated natural substances and their methylated derivatives (1-8) neither inhibited superoxide anion radical formation in the XXO assay nor suppressed TPA-induced superoxide anion generation in HL-60 cell line. Corynesidone A (1) inhibited aromatase activity with an IC50value of 5.30 μM. © 2009 Elsevier Ltd. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleAromatase inhibitory, radical scavenging, and antioxidant activities of depsidones and diaryl ethers from the endophytic fungus Corynespora cassiicola L36en_US
Appears in Collections:Scopus 2006-2010

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