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Title: Facile synthesis of N-aroylurea analogs as potential antioxidants
Authors: Kitti Amornraksa
Apilak Worachartcheewan
Virapong Prachayasittikul
Thammasat University
Mahidol University
Keywords: Agricultural and Biological Sciences;Computer Science;Earth and Planetary Sciences;Engineering;Materials Science;Mathematics
Issue Date: 1-Jan-2009
Citation: European Journal of Scientific Research. Vol.31, No.4 (2009), 510-518
Abstract: N,N'-Dicyclohexylcarbodiimide (DCC) is a widely used dehydrating and oxidizing agents for the synthesis such as proteins, amides and esters. The study reports synthetic application of the DCC to form N-aroylurea analogs and their antioxidant activity. Results showed that N-benzoyl-N,N'-dicyclohexylurea (Ia), N,N'-dicyclohexyl-N-3,5-dinitrobenzoylurea (Ib) and N,N'-dicyclohexyl-N-[(E)-3-phenylacryloyl]urea (Ic) were readily accomplished by facile one pot reaction of DCC with benzoic or cinnamic acid in the presence of triethylamine. The reaction took place via rearrangement of O-aroylurea intermediate to furnish relatively good yields of the analogs Ia-c. In addition, at 200 μg/mL, the urea analog Ic starts to mimic superoxide scavenging activity. © EuroJournals Publishing, Inc. 2009.
ISSN: 1450202X
Appears in Collections:Scopus 2006-2010

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