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Title: Metabolites from the endophytic mitosporic Dothideomycete sp. LRUB20
Authors: Porntep Chomcheon
Suthep Wiyakrutta
Nongluksna Sriubolmas
Nattaya Ngamrojanavanich
Chulabhorn Mahidol
Somsak Ruchirawat
Prasat Kittakoop
Chulabhorn Research Institute
Chulalongkorn University
Mahidol University
The Institute of Science and Technology for Research and Development, Mahidol University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2009
Citation: Phytochemistry. Vol.70, No.1 (2009), 121-127
Abstract: The endophytic mitosporic Dothideomycete sp. LRUB20 was found to produce pyrone derivatives, dothideopyrones A-D (1, 3, 4, and 5), together with seven known compounds, including questin (9), asterric acid (10), methyl asterrate (11), sulochrin (12), and eugenitin (13), 6-hydroxymethyleugenitin (14), and cis, trans-muconic acid (15). Dothideopyrone D (5) and its acetate derivative 6 exhibited moderate cytotoxic activity. This is the first report on a naturally occurring muconic acid, which is commonly known as a biomarker in environments after exposure to benzene and phenol (or derivatives). Interestingly, the LRUB20 fungus could produce muconic acid in relatively high yield (47.8 mg/L). The utility of endophytic fungi in the field of white biotechnology is discussed. © 2008 Elsevier Ltd. All rights reserved.
ISSN: 00319422
Appears in Collections:Scopus 2006-2010

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