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dc.contributor.authorSupaluk Prachayasittikulen_US
dc.contributor.authorKetkaew Buttrawongen_US
dc.contributor.authorApilak Worachartcheewanen_US
dc.contributor.authorSomsak Ruchirawaten_US
dc.contributor.authorVirapong Prachayasittikulen_US
dc.contributor.otherSrinakharinwirot Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChulabhorn Graduate Instituteen_US
dc.identifier.citationEuropean Journal of Scientific Research. Vol.38, No.4 (2009), 596-603en_US
dc.description.abstractBioactive azafluorenone alkaloids from Polyalthia debilis were previously reported. Herein, bioactive root extracts of P. debilis (hexane and methanol) with antimalarial, antimicrobial and cytotoxic activities were further explored. Upon repeated chromatographic isolations of the extracts gave triterpenes; 3-acetylaleuritolic acid (1), suberosol (4) and stigmasterol (2) together with a mixture of stigmasterol and β-sitosterol (3) including many fractions of triterpenes mixture. Compounds 1 and 4 were isolated from the P. debilis for the first time. The sterol 3 exhibited antifungal action against Saccharomyces cerevisiae ATCC 2601 with a minimum inhibitory concentration of 64 μg/mL. Some of the isolated fractions were also shown to be antifungals. The results provide medicinal applications of the plant species. © EuroJournals Publishing, Inc. 2009.en_US
dc.rightsMahidol Universityen_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectComputer Scienceen_US
dc.subjectEarth and Planetary Sciencesen_US
dc.subjectMaterials Scienceen_US
dc.titleIsolation of bioactive metabolites from root extracts of Polyalthia debilisen_US
Appears in Collections:Scopus 2006-2010

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