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dc.contributor.authorY. Suputtamongkolen_US
dc.contributor.authorC. Suttinonten_US
dc.contributor.authorK. Niwatayakulen_US
dc.contributor.authorS. Hoontrakulen_US
dc.contributor.authorR. Limpaiboonen_US
dc.contributor.authorW. Chierakulen_US
dc.contributor.authorK. Losuwanaluken_US
dc.contributor.authorW. Saisongkorken_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherMaharaj Nakhon Ratchasima Hospitalen_US
dc.contributor.otherMuang Loei Ram Hospitalen_US
dc.contributor.otherChumphon Hospitalen_US
dc.contributor.otherUdonthani Hospitalen_US
dc.contributor.otherBanmai Chaiyapod Hospitalen_US
dc.contributor.otherMinistry Public Health Thailanden_US
dc.date.accessioned2018-09-13T06:20:38Z-
dc.date.available2018-09-13T06:20:38Z-
dc.date.issued2009-01-01en_US
dc.identifier.citationAnnals of the New York Academy of Sciences. Vol.1166, (2009), 172-179en_US
dc.identifier.issn17496632en_US
dc.identifier.issn00778923en_US
dc.identifier.other2-s2.0-67649718325en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67649718325&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/27090-
dc.description.abstractScrub typhus and murine typhus are widespread in Thailand. Clinical manifestations of both diseases are nonspecific and vary widely. Acute undifferentiated fever (AUF), with or without organ dysfunction, is a major clinical presentation of these two diseases. The epidemiology and clinical manifestations including severe complications of scrub typhus and murine typhus in Thailand are summarized. Sixteen hundred and sixty-three patients with AUF were studied in six hospitals in Thailand between 2000 and 2003. Scrub typhus and murine typhus were diagnosed in 16.1% and 1.7% of them, respectively. Clinical spectrum of murine typhus was similar to scrub typhus. Hepatic dysfunction and pulmonary involvement were common complications. Multi-organ dysfunction mimicking sepsis syndrome occurred in 11.9% of patients with scrub typhus. The mortality of severe scrub typhus varied from 2.6% to 16.7%. Awareness that scrub typhus and murine typhus are prominent causes of AUF in adults in Thailand improves the probability of an accurate clinical diagnosis. Early recognition and appropriate treatment reduces morbidity and mortality. Results from recent clinical studies from Thailand indicated that rational antimicrobial therapy would be doxycycline in mild cases and a combination of either cefotaxime or ceftriaxone and doxycycline in severe cases. Azithromycin could be considered as an alternative treatment when doxycycline allergy is suspected. This would be either curative, or have no ill effect, in the majority of instances. Failure to improve or defervesce within 48 hours would indicate the need to perform a thorough re-evaluation of clinical findings and initial laboratory investigation results, as well as a need to change antibiotic. © 2009 New York Academy of Sciences.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67649718325&origin=inwarden_US
dc.subjectArts and Humanitiesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleEpidemiology and clinical aspects of rickettsioses in Thailanden_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1111/j.1749-6632.2009.04514.xen_US
Appears in Collections:Scopus 2006-2010

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