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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/27094
Title: Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4
Authors: Kiyoshi Kikuchi
Salunya Tancharoen
Fumiyo Matsuda
Kamal Krishna Biswas
Takashi Ito
Yoko Morimoto
Yoko Oyama
Kazunori Takenouchi
Naoki Miura
Noboru Arimura
Yuko Nawa
Xiaojie Meng
Binita Shrestha
Shinichiro Arimura
Masahiro Iwata
Kentaro Mera
Hisayo Sameshima
Yoshiko Ohno
Ryuichi Maenosono
Yutaka Tajima
Hisaaki Uchikado
Terukazu Kuramoto
Kenji Nakayama
Minoru Shigemori
Yoshihiro Yoshida
Teruto Hashiguchi
Ikuro Maruyama
Ko ichi Kawahara
Division of Laboratory and Vascular Medicine
Omuta City General Hospital
Mahidol University
Faculty of Medicine
Kagoshima University Faculty of Medicine
Faculty of Agriculture
Kurume University School of Medicine
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 25-Dec-2009
Citation: Biochemical and Biophysical Research Communications. Vol.390, No.4 (2009), 1121-1125
Abstract: Aquaporin-4 (AQP4) plays a role in the generation of post-ischemic edema. Pharmacological modulation of AQP4 function may thus provide a novel therapeutic strategy for the treatment of stroke, tumor-associated edema, epilepsy, traumatic brain injury, and other disorders of the central nervous system (CNS) associated with altered brain water balance. Edaravone, a free radical scavenger, is used for the treatment of acute ischemic stroke (AIS) in Japan. In this study, edaravone significantly reduced the infarct area and improved the neurological deficit scores at 24 h after reperfusion in a rat transient focal ischemia model. Furthermore, edaravone markedly reduced AQP4 immunoreactivity and protein levels in the cerebral infarct area. In light of observations that edaravone specifically inhibited AQP4 in a rat transient focal ischemia model, we propose that edaravone might reduce cerebral edema through the inhibition of AQP4 expression following cerebral infarction. © 2009 Elsevier Inc. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70549090013&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/27094
ISSN: 10902104
0006291X
Appears in Collections:Scopus 2006-2010

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