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Title: Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus
Authors: Nattha Ingavat
Jeffrey Dobereiner
Suthep Wiyakrutta
Chulabhorn Mahidol
Somsak Ruchirawat
Prasat Kittakoop
Center for Environmental Health
Brandeis University
Mahidol University
Chulabhorn Research Institute
The Institute of Science and Technology for Research and Development, Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 30-Nov-2009
Citation: Journal of Natural Products. Vol.72, No.11 (2009), 2049-2052
Abstract: A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by comparison of the 1H NMR spectrum of its benzoylated derivative with those of benzoylated erythritol (7) and D-threitol (8), as well as by cellulose-based chiral HPLC analysis. Aspergillusol A (4) selectively inhibited α-glucosidase from the yeast Saccharomyces cerevisiae, but it was inactive toward the α-glucosidase from the bacterium Bacillus stearothermophilus. © 2009 American Chemical Society and American Society of Pharmacognosy.
ISSN: 01633864
Appears in Collections:Scopus 2006-2010

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