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|Title:||Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus|
Center for Environmental Health
Chulabhorn Research Institute
The Institute of Science and Technology for Research and Development, Mahidol University
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Journal of Natural Products. Vol.72, No.11 (2009), 2049-2052|
|Abstract:||A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by comparison of the 1H NMR spectrum of its benzoylated derivative with those of benzoylated erythritol (7) and D-threitol (8), as well as by cellulose-based chiral HPLC analysis. Aspergillusol A (4) selectively inhibited α-glucosidase from the yeast Saccharomyces cerevisiae, but it was inactive toward the α-glucosidase from the bacterium Bacillus stearothermophilus. © 2009 American Chemical Society and American Society of Pharmacognosy.|
|Appears in Collections:||Scopus 2006-2010|
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