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Title: Pinostrobin from Boesenbergia pandurata Is an inhibitor of Ca 2+-Signal-Mediated Cell-Cycle regulation in the Yeast Saccharomyces cerevisiae
Authors: Wachirasak Wangkangwan
Saipin Boonkerd
Warinthorn Chavasiri
Kasama Sukapirom
Kovit Pattanapanyasat
Ngampong Kongkathip
Tokichi Miyakawa
Chulalongkorn University
Mahidol University
Kasetsart University
Hiroshima University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Immunology and Microbiology
Issue Date: 19-Aug-2009
Citation: Bioscience, Biotechnology and Biochemistry. Vol.73, No.7 (2009), 1679-1682
Abstract: Upon searching plant extracts for inhibitors of the Ca2+signaling pathway using the zds1δ-yeast proliferation based assay, a crude rhizome extract of Boesenbergia pandurata was found to be strongly positive, and from this extract pinostrobin, alpinetin, and pinocembrin chalcone were isolated as active components. Further biochemical experiments confirmed that pinostrobin possesses inhibitory activity on the Ca2+signals involved in the control of G2/M phase cell cycle progression in Saccharomyces cerevisiae.
ISSN: 13476947
Appears in Collections:Scopus 2006-2010

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